Neopterin: Biomarker of cell-mediated immunity and potent usage as biomarker in silicosis and other occupational diseases
نویسندگان
چکیده
Neopterin is regarded as an early biomarker of the cellular immune response. This low molecular mass compound belongs to the class of pteridine and is a metabolite of guanosine triphosphate, which is produced by the activated macrophages and dendritic cells after stimulation with gamma-interferon. An international group acknowledges the fact that the levels of serum neopterin can be used as a marker of the effect of exposure to silica and other occupational diseases. The determination of neopterin is an innovative tool for monitoring diseases associated with the activation of cell-mediated immunity.
منابع مشابه
The Potential Role of Neopterin as a Biomarker for Silicosis
Human macrophages and dendritic cells produce Neopterin derivates after stimulation with interferon-γ and serves as a marker of activated cell-mediated immune response. Aim: Assessment of serum neopterin levels in patients with different X-ray chances about silicosis. Methods: The serum neopterin concentrations were measured using ELISA in 60 patients with silicosis, according to conventional X...
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عنوان ژورنال:
دوره 12 شماره
صفحات -
تاریخ انتشار 2008